Pritish Nandy Communication Productions' latest offering is Mastizaade, a film that's about two sex addicts. They are Sunny Kele (Tussshar Kapoor) and Aditya Chotiya (Vir Das). While Sunny Kele falls in love with Laila Lele (Sunny Leone), Aditya falls in love with Lilly Lele (Sunny Leone). Laila and Lilly run a sex-addiction clinic.
Matters become worse from Laila's gay brother Das (Suresh Menon) also falls in love with Sunny Kele, who is on the verge of getting married to a wheel chair bound Deshpremi (Shaad Randhawa).
Between Laila and Das, who gets Sunny Kele, what happens in the end in this maniac comedy of errors and mistaken identities is what forms the rest of the film.